grapefruit and estrogen

It’s not just grapefruit that may have an effect with estrogen. Some of the more commonly used birth control pills prescribed in the U.S. include: Learn More: See a list of other popular birth control options. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. In contrast, fresh grapefruit juice, bottled grapefruit juice, and grapefruit soda intake all had significant lowering effects on estradiol. It may also make medications stay in the body longer. More rare but serious side effects have been described when estrogen was combined with large quantities of grapefruit. While grapefruits do have their positive effects, it’s important to understand that it may cause a drug-food interaction with estrogen replacement therapy.If you’re taking hormones for menopause symptoms, then it may be best to stay away from this citrus. Grapefruit juice interacts with many different medications, including estrogen hormone imbalance treatment. Reduced blood levels of estrogens may result in a decrease in birth control effectiveness and changes in monthly bleeding. Let's look into this a little further. Mainly, readers wanted to better understand the estrogen effect. In most cases, you should be able to continue consuming grapefruit with birth control without any issues. If you eat grapefruit or drink grapefruit juice, be sure to tell your doctor, pharmacist or other health care provider. Cirmi S, Maugeri A, Ferlazzo N, et al. A study in 59 women found that eating grapefruit can increase levels of endogenous estrogen (but not grapefruit juice and estrogen).4 The results showed that whole grapefruit intake had significant effects on endogenous estrone-3-sulfate. Higher estrogen levels might cause side effects like breast tenderness, nausea, and changes in uterine bleeding. An estimated 21% of American households purchase grapefruit juice, with many more eating the fruit whole. This effect is variable and may not be clinically significant in every person. Grapefruit and Birth Control Pills: Your Questions Answered, We comply with the HONcode standard for trustworthy health information -. If you need to avoid grapefruit while you are taking a certain drug, it is best not to consume grapefruit at all, either the juice or whole fruit.3. However, some researchers warn against consuming grapefruits with progesterone due to the potentially similar effects.

One of these enzymes is the CYP3A4 enzyme, primarily found in your liver and digestive tract. It has been established that "serum estrogen concentration is associated with postmenopausal breast cancer risk". Some other effects you may notice is increased bloating, tiredness, or even weight gain. However, some medications can increase (induce) the activity of the CYP3A4 enzyme , boost estrogen break down and possibly lower the effectiveness of your birth control pill.

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