The melting point of benzocaine is 88–90 °C,[25] and the boiling point is about 310 °C. [medical citation needed], It was first synthesised in 1890 in Germany and approved for medical use in 1902.[2]. She was successfully resuscitated without sequelae. Carlos A. Artime, Antonio Sanchez, in Benumof and Hagberg's Airway Management, 2013, Benzocaine is a water-insoluble ester-type local anesthetic agent that is mainly useful for topical application. Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It is used in many countries as a component of some free-sale formulations for topical use, for example in skin creams, as a dry powder for skin ulcers, as throat lozenges, and as teething formulations for young children. This information is not specific medical advice and does not replace information you receive from your health care provider. You may report side effects to FDA at 1-800-FDA-1088. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. You must talk with your healthcare provider for complete information about the risks and benefits of using acetic acid/antipyrine/benzocaine/u-polycosanol. Oropharyngeal anesthesia is quickly obtained. The most severe cases have led to neurologic hypoxic injury, myocardial infarction, and death. [33], Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859–1946),[34] in the town of Eberbach[35] and introduced to the market in 1902 under the name "Anästhesin". Daniel A. Haas, Christine L. Quinn, in Pharmacology and Therapeutics for Dentistry (Seventh Edition), 2017. In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid, Cream (ex. Benzocaine may cause allergic reactions. [27] Whilst giving a numbing effect similar to cocaine, users prefer Benzocaine as it is a better bulking and binding agent that can't be detected once mixed. It may also be used to help remove a buildup of earwax. Where is the neutral compound after conversion. Well they are at two opposite ends of the ph scale. Benzocaine is structurally similar to procaine except that it lacks a terminal diethyl amino group. For children, gently pull the earlobe down and back to straighten the ear canal. Question = Is SCN- polar or nonpolar ? [26] The density of benzocaine is 1.17 g/cm3. Benzocaine is indicated to treat a variety of pain-related conditions. Check the label on the medicine for exact dosing instructions. [medical citation needed] Applying an oral anesthetic and consuming beverages before going to bed can be particularly hazardous. Pennsauken, NJ; 2006 Sept. D'Ans-Lax, Taschenbuch für Chemiker und Physiker, 4. It may be used with antibiotics given by mouth to treat certain ear infections. It is not known if this medicine is found in breast milk. [36][37], A bath solution of benzocaine has been used to anesthetize amphibians for surgery. Lanacane - active ingredient 3% Benzocaine), This page was last edited on 9 October 2020, at 22:22. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780444537171003668, URL: https://www.sciencedirect.com/science/article/pii/B9781455703067001094, URL: https://www.sciencedirect.com/science/article/pii/B9780123738981500255, URL: https://www.sciencedirect.com/science/article/pii/B9780323046794100127, URL: https://www.sciencedirect.com/science/article/pii/B978032339307200014X, URL: https://www.sciencedirect.com/science/article/pii/B9780444521668500029, URL: https://www.sciencedirect.com/science/article/pii/B9781437727647000117, URL: https://www.sciencedirect.com/science/article/pii/S0378608009031110, URL: https://www.sciencedirect.com/science/article/pii/B9780323065245000143, Meyler's Side Effects of Drugs (Sixteenth Edition), Louisa J. Rahilly DVM, DACVECC, Deborah C. Mandell VMD, DACVECC, in, Small Animal Critical Care Medicine (Second Edition), Anesthesia and Restraint of Laboratory Fish, Anesthesia and Analgesia in Laboratory Animals (Second Edition), Handbook of Veterinary Pain Management (Second Edition), Pharmacology and Therapeutics for Dentistry (Seventh Edition), Preparation of the Patient for Awake Intubation, Stephan A. Schug, ... Joshua H.P. [31][32] In industrial practice, the reducing agent is usually iron and water in the presence of a little acid. Brand Name: PR Otic. Store away from heat, moisture, and light. Do not share it with other people. 10% HCl. Bethesda, MD: American Society of Health-System Pharmacists; 2007: 2844-5. What is the neutral compound. Relatively high concentrations of local anesthetic are required to be effective topically, increasing tissue penetration and the risk of subsequent toxicity. Benzocaine Base is...well....a base. Poorly soluble in aqueous fluid, benzocaine tends to remain at the site of application and is not readily absorbed into the systemic circulation. As levels increase to 20% to 30%, patients may develop chest pain, ischemic changes on ECG, hypotension, altered mental status, syncope, or coma. Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. It is metabolized through hydrolysis by plasma cholinesterase. R.S. The risk of methemoglobinemia is still a consideration, and cases of severe toxicity have been reported.115,116, EMLA cream (eutectic mixture of local anesthetic) contains 2.5% lidocaine and 2.5% prilocaine and is considered a topical anesthetic for use on intact skin. Hruby, in Synthesis of Essential Drugs, 2006. Lau, in, A type 1 immediate hypersensitivity reaction to topical, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, xPharm: The Comprehensive Pharmacology Reference. McEvoy GK, ed. Clearly this lacks the tertiary amine component, so not surprisingly, it is less active as an injectable drug. It can be prepared from PABA and ethanol[24] by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. This information should not be used to decide whether or not to take acetic acid/antipyrine/benzocaine/u-polycosanol or any other medicine. Symptoms of methemoglobinemia usually occur within minutes to hours of applying benzocaine, and can occur upon the first-time use or after additional use.[18]. It is also used under the names anestezin, dermoplast, and others. It is … The HCl salt of benzocaine can be prepared as a stock solution of 100 g/L, which should be stored in a dark container and protected from light. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. Intradermal skin tests confirmed hypersensitivity to benzocaine. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ether. Share on Facebook Tweet on Twitter Plus on Google+. Call your doctor for medical advice about side effects. Benzocaine has been reported to cause methemoglobinemia in some species (e.g., sheep), which may limit its widespread use in clinical practice. Khursheed R. Mama, in Handbook of Veterinary Pain Management (Second Edition), 2009. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Cetylite Industries. Benzocaine has been used to varying degrees in dentistry to provide anesthesia of the gums and buccal mucosa and for cutaneous analgesia. Cetacaine (benzocaine 14%, tetracaine 2% and butamben 2%) spray, gel and liquid prescribing information. Benzocaine, used as a spray for topical anesthesia of mouth and throat, can result in methemoglobinemia if excessive amounts are used in the form of multiple sprays or spraying the area for a longer duration than recommended. Question : Is aspirin an acid or base or neutral ? If you get acetic acid/antipyrine/benzocaine/u-polycosanol in any of these areas, rinse right away with cool water. Check with your pharmacist about how to dispose of unused medicine. From FDA website. Methemoglobin is reduced through methemoglobin reductase, and this process is accelerated by intravenous methylene blue (1 to 2 mg/kg). Lau, in Side Effects of Drugs Annual, 2009. Is SCN- polar or nonpolar? Should symptomatic methemoglobin occur, treatment is with methylene blue 1 to 2 mg/kg IV given over 5 minutes.110,111. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to acetic acid/antipyrine/benzocaine/u-polycosanol. Favorite Answer. Share this. Lexicomp Online, Adult and Pediatric Lexi-Drugs Online, Hudson, Ohio: Lexi-Comp, Inc.; 2013; April 15, 2013. Some medical conditions may interact with acetic acid/antipyrine/benzocaine/u-polycosanol. Keep acetic acid/antipyrine/benzocaine/u-polycosanol out of the reach of children and away from pets. The HCL … If you have questions about side effects, contact your health care provider. Store acetic acid/antipyrine/benzocaine/u-polycosanol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Although most patients tolerate benzocaine airway topicalization without any adverse effects, it is not possible to identify in advance those patients who are at risk for significant methemoglobinemia. Sultan Healthcare. For adults, gently pull the earlobe up and back to straighten the ear canal. An example is Novocain, which is one of the most successful synthetic drugs in this family in use. Only your health care provider has the knowledge and training to decide which medicines are right for you. Benzocaine formulations are available in concentrations of 1–20%. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Benzocaine is a derivative of procaine in which the amino terminus is lacking. A benzocaine containing anti-itch medication provides temporary relief with subsequent return of itching caused by the benzocaine-induced contact dermatitis. A mucosal gel patch (containing 36 mg per 2-cm-long × 1-cm-wide patch) is also available.

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